System is Vista Ultimate 32-bit with RAID 10 on Intel ICH8R chipset. A couple of weeks ago I tried running a .mov file using Apple QuickTime software (latest version) and that is when things started to go downhill. The file seemed very slow to load and eventually QuickTime crashed after a lot of persuasion. Once QuickTime was closed, I was notified of a RAID error through the Intel Matrix Storage Console but the same thing will happen if you reboot during the lockup as well.
Thinking the worst, I promptly went about getting the affected drive replaced, naturally thinking it was dead. I got the drive replaced without any issues from the friendly chaps at Seagate, plugged it in and rebuilt the array without any issues and with everything back to normal. Just recently the exact same event occurred and I knew the chances of that exact same set of occurrences happening was extremely rare.