"In some tests over the last couple of days and some searching of the official Folding@ Home forums, I’ve discovered that anyone who’s wanting to fold on Windows Vista may have some issues with the current versions of the software (the 5.03 Standard Graphical version won’t run through the setup process on most installations of Vista, and you need to adjust some settings to get the 5.04 Console Only version to run fully)."
Check it out at PC Apex.