ExtremeTech has taken a closer look at the universal Logitech Harmony One Remote:
If you're unfamiliar with Logitech's Harmony remotes, here's the concept in a nutshell: you set up the remote by plugging it into your computer and telling a web-based application what gear you own. Then you set up "Activities" like "Watch DVD," "Watch TV," or "Play Xbox," describing all the different input settings for all your different gear. Many universal remotes work with all your stuff, but in order to switch to the DVD player, you have to turn this thing to Input 4, that other thing to "DVD," turn on the DVD player, switch the remote over to DVD control, and so on. On a Harmony, you press the Watch DVD activity you set up and it does all those things for you.
Check it out over here. The Harmony One costs a staggering $250 but according to the reviewer it's definitely worth it as it can replace your entire pile of current remotes and has great ergonomics, very broad support and a very usable touch screen.