Antec's new Skeleton chassis is meant for gamers and perpetual tinkerers. The motherboard sits on the upper level. One the lower level, a power supply, two optical drives and two hard drives can be fitted.
The ~220mm fan blows down onto the motherboard and creates enough airflow to keep everything well cooled. It has three speeds, and a unique LED feature.
The site says Antec is also working on a mini Skeleton case for mini-ITX systems.