A photo of the upcoming Toxic HD 4850 graphics card from Sapphire was published by FUD Zilla. This card uses a non-reference design and features a Zalman cooler. The card will be an overclocked edition but the clockspeeds aren't known yet.
As far as we could tell from the picture, Sapphire's Toxic HD 4850 will be cooled by Zalman's VF900-Cu cooler which comes in combination with small aluminum memory heatsinks. The new card uses Sapphire's blue PCB which is very similar to the reference one, and as the cooler is changed Sapphire had to use a copper heatsink to cool the card's VRM.