I'd like to present a new program which features a real good payout, one of the best I've ever seen. It's called Chitika eMiniMalls. I saw it a few weeks ago and I decided to sign up because the advertisments looked good and relevant.
Their eMiniMalls advertising program works on a pay-per-click base. Each time one of your visitors clicks on one of the ads you will receive some money. I can't tell how much it is because of their terms and conditions but this program has one of the highest earnings per clicks I've ever seen.
They offer a wide range of ad formats and you can specify the colors, default tab, and more. You can check out their ad formats over here. You can also use it in combination with AdSense if you turn the ads to non-contextual. Targeting the ads is very easy because Chitika allows you to manually target pages with the ch_query tag. If you use PHP or ASP you can easily target the ads to the titles of your articles and in many cases they are really relevant.
Chitika pays you very fast by PayPal, check or wire transfer. The only bad thing about Chitika's service is that the stats are only updated once a day.
You can try Chitika by signing up over here.
If you have any questions please feel free to post a comment.