Windows Central claims they received confirmation from their sources and suggests this feature may be one of the reasons why major game developers are jumping onboard the Universal Windows Apps (UWA) train:
Previously, we were unable to ascertain whether Game Mode would be a feature restricted to games built for the Universal Windows Platform (UWP), but it does appear that this could be the case. Our information states that games developed for the Windows 10, Xbox One, and Project Scorpio ecosystem specifically need to be "Game Mode enabled" Universal Windows Apps (UWA).
This means that developers using Game Mode enabled UWP today to build games for Xbox One at 900-1080p and up to 4K for Windows 10 PCs are ready to deploy those games for Project Scorpio, with over 95% of the existing project code intact. This could explain why we're already seeing major players jump on the UWA-train, with Resident Evil 7 set for a Windows 10 Store debut on January 24th, 2017. If it is a Game Mode enabled UWA, Resident Evil 7 is ready for true 4K on Project Scorpio as a result, unpacking its 4K PC textures and settings when it installs on the console.