Interestingly, one of the items listed in the known issues section is that systems may hang after extended period of use. This applies only to configurations with 12 GPUs, so this is primarily for miners or GPGPU users.
Final Fantasy® XV Warhammer®: Vermintide II DOTA®2: Up to 6% faster FPS using Radeon Software Adrenalin Edition 18.3.1 on the Radeon™ RX 580 (8GB) graphics card than with Radeon Software Adrenalin Edition 17.12.1 at 3840x2160 (1440p).RS-218
Radeon Chill hotkey may fail to reset when Radeon Settings is restored to defaults. Sea of Thieves™ may experience an intermittent application hang or crash during gameplay. Middle-earth™: Shadow of War may experience texture flickering on trees or hills when using multi GPU enabled system configurations. World of Tanks™ may experience color corruption when changing some game settings in multi GPU enabled system configurations.
A random system hang may be experienced after extended periods of use on system configurations using 12 GPU's for compute workloads. Destiny 2™ may experience an application hang in the mission "Heist" on some Radeon GCN1.0 products. Destiny 2™ may experience long load times when the application has been open for long periods of time. Radeon Overlay may intermittently fail to enable when toggled in some games. FFmpeg application may experience corrupted output for H264 video streams. Resizing Radeon Settings may cause the window to intermittently stutter. Final Fantasy® XV may experience minor stutter during some particle effects. A workaround is to disable the "Geomapping" setting in game.