Today we're publishing at the Microsoft Download Center a recommended final compatibility update for users of Windows Vista and the Apple iPod; this same update will be automatically available via Windows Update on Tuesday 22 May. The release is for users worldwide and works with the latest version of Apple iTunes to correct an issue that caused some iPods to become corrupted when ejecting them using Windows Explorer or the "Safely Remove Hardware" function in the System Tray.
The long and short of it is this: Apple and Windows have partnered together to ensure a great experience in using Windows Vista with iTunes and the iPod, and both companies recommend you download this update.
Patches and updates
Product page: here