X-bit Labs has written a review of the Asus P5E motherboard:
Intel X38 chipset was initially intended as new core logic set for expensive mainboards. In fact it implies that X38 came to replace the pretty old i975X that doesn’t officially support promising 45nm Penryn processors and comes with a not very up-to-date South Bridge. At least, according to Intel.
We believe that the situation should be regarded a little bit differently. i975X that has been out there for a considerable while now, it is not longer appealing to computer enthusiasts who have turned to Intel P35 based mainboards these days. The only trump of the i975X chipset - support of Crossfire as PCI Express x8 + PCI Express x8 – is actually not such a great advantage at all. First, Intel P35 chipset can also support Crossfire (although as PCI Express x16 + PCI Express x4)..
Check it out over here. Overall the motherboard seems to perform pretty well but the reviewer says you may encounter some clearance problems if you try to install massive processor coolers.