The Santy problem originally flared up a week ago as bulletin board Web sites found their pages erased and defaced by the worm's own text. The worm spread by targeting pages that used vulnerable versions of the PHP Bulletin Board (phpBB) software, and used Google to locate those pages.Perl.Santy.B is written in Perl script and it attackts vulnerable phpBB 2.x forums. Just like the original Santy it uses search engines to find exploitable forums.
Read more about this worm at ZDNet.
More info about the Santy.e worm which doesn't solely attacks phpBB but also other PHP scripts can be found here.